T-Cell Activation

T-Cell Activation, CD8 Subset

Various subgroups of CD8⁺ T lymphocytes do not only demonstrate cytotoxic effects, but also serve important regulatory roles in the body’s immune response. In particular, CD8⁺ regulatory T cells (CD8⁺ Tregs), which possess important immunosuppressive functions, are able to effectively block the overreacting immune response and maintain the body’s immune homeostasis. In recent years, studies have identified a small set of special CD8⁺ Tregs that can recognize major histocompatibility complex class Ib molecules, more specifically Qa-1 in mice and HLA-E in humans,

1. Absolute CD 3

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1. Absolute CD 3
#	Source	Date	Value	Range
1.	UT1	07/30/2026	736	622-2402 (/uL)

Excerpt:

QUICK ANSWER

The absolute CD3 count measures the total number of T lymphocytes in your blood. All T cells express the CD3 protein on their surface — so “absolute CD3” is essentially the total T cell count.

2. % CD 3 Pos. Lymph.

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2. % CD 3 Pos. Lymph.
#	Source	Date	Value	Range
1.	UT1	07/30/2026	66.9	57.5-86.2 (%)

Excerpt:

The CD3 (Total T-Lymphocytes) Test is a blood test that measures the total number of T-cells circulating in the bloodstream. T-cells are a core component of the immune system. They help recognize infections, eliminate infected or abnormal cells, and coordinate immune responses with other white blood cells.

3. Absolute CD 4 Helper

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3. Absolute CD 4 Helper
#	Source	Date	Value	Range
1.	UT1	07/30/2026	515	359-1519 (/uL)

Excerpt:

Overview

The CD4 (Helper T-Cells) Test is a blood test that measures the number or percentage of CD4 cells in the bloodstream. CD4 cells are a specialized group of T-lymphocytes and are central to how the immune system functions. They are often called “helper cells” because they coordinate and direct the activity of other immune cells, rather than attacking infections on their own.

4. % CD 4 Pos. Lymph.

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4. % CD 4 Pos. Lymph.
#	Source	Date	Value	Range
1.	UT1	07/30/2026	46.8	30.8-58.5 (%)

Excerpt:

The CD4 percentage (CD4%) is the percentage of white blood cells (lymphocytes) that are CD4 cells.

The immune system contains lots of different cells. The two main types of lymphocytes are T cells and B cells. CD4 cells are a type of T cell. So the CD4% looks at the CD4 count in relation to other immune cells.

5. Absolute CD 8 (Supp)

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5. Absolute CD 8 (Supp)
#	Source	Date	Value	Range
1.	UT1	07/30/2026	234	109-897 (/uL)

Excerpt:

This figure is rarely used for making treatment decisions.

CD4 and CD8 are two types of white blood cells in your blood. CD4 cells are also called T-helper cells, T-suppressor cells, and cytotoxic T-cells. They help the body fight infections. CD8 cells are also called cytotoxic T-lymphocytes. They help fight cancer and germs that live inside your cells (intracellular pathogens).

6. % CD 8 Pos. Lymph.

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6. % CD 8 Pos. Lymph.
#	Source	Date	Value	Range
1.	UT1	07/30/2026	21.3	12.0-35.5 (%)

Excerpt:

The CD4 percentage (CD4%) is the percentage of white blood cells (lymphocytes) that are CD4 cells.

7. CD4/CD8 Ratio

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7. CD4/CD8 Ratio
#	Source	Date	Value	Range
1.	UT1	07/30/2026	2.2	0.92-3.72

Excerpt:

What is this test?

This test looks at the ratio of 2 important types of white blood cells in your blood.

Lymphocytes are a type of white blood cell in your immune system. This test looks at 2 of them, CD4 and CD8. CD4 cells lead the fight against infections. CD8 cells can kill cancer cells and other invaders.

8. Abs.CD8+HLA-DR+Lymph

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8. Abs.CD8+HLA-DR+Lymph
#	Source	Date	Value	Range
1.	UT1	07/30/2026	26	0-117 (/uL)

Excerpt:

About % CD8+ HLA-DR

Your immune system has a powerful attack force called CD8 T cells. These are the cells that hunt down virus-infected cells, cancer cells, and other internal threats. When they switch into active combat mode, they display a protein on their surface called HLA-DR. This test counts what percentage of your CD8 cells are currently flying that activation flag.

9. % CD8+HLA-DR+Lymphs

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9. % CD8+HLA-DR+Lymphs
#	Source	Date	Value	Range
1.	UT1	07/30/2026	2.4	0-4.9 (%)

Excerpt:

Introduction

Hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) are rare, life-threatening hyper-acute manifestations due to detrimental overactivation of the immune system [1–3]. The diagnosis is based on the identification of at least five out of eight clinical and laboratory criteria as defined by the Histiocyte Society. Specifically designed criteria are available for the diagnosis of MAS, the HLH associated with rheumatic diseases.

10. % CD3+CD25+Lymphs

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10. % CD3+CD25+Lymphs
#	Source	Date	Value	Range
1.	UT1	07/30/2026	28.8 H	4.9-25.9 (%)

Excerpt:

CD25 is the receptor for IL2 and is expressed on activated T cells, B cells, and macrophages. CD25 is expressed in certain types of B-cell lymphoma (hairy cell leukemia) and T-cell lymphoma (adult T-cell lymphoma/leukemia [ATLL]).

The interleukin-2 receptor is designated CD25. Originally isolated from T-lymphocytes, it is now known to be expressed on hairy cell leukemia and adult T-cell leukemia/lymphoma, classical Hodgkin lymphoma, and a subset of other peripheral T-cell lymphomas.

11. Abs. CD3+CD25+Lymphs

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11. Abs. CD3+CD25+Lymphs
#	Source	Date	Value	Range
1.	UT1	07/30/2026	317	79-535 (/uL)

Excerpt:

12. % CD8+CD38+Lymphs

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12. % CD8+CD38+Lymphs
#	Source	Date	Value	Range
1.	UT1	07/30/2026	3.8	0.0-17.7 (%)

Excerpt:

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), that spread around the world during the past 2 years, has infected more than 260 million people worldwide and has imposed an important burden on the healthcare system. Several risk factors associated with unfavorable outcome were identified, including elderly age, selected comorbidities, immune suppression as well as laboratory markers. The role of immune system in the

13. Abs. CD8+CD38+Lymphs

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13. Abs. CD8+CD38+Lymphs
#	Source	Date	Value	Range
1.	UT1	07/30/2026	42	0-381 (/uL)

Excerpt:

We investigated the relationship between three prognostic markers, CD4 lymphocyte count, serum β₂-microglobulin (β₂M) levels, and CD8⁺, CD38⁺ lymphocyte percent, and the association with the rate of development of AIDS. The markers were measured regularly throughout follow-up in 224 patients. The risk of developing AIDS during follow-up was investigated using Cox proportional hazards models. Time-updated values of the prognostic markers were used, which modeled the risk of AIDS according to the latest measurement of the marker rather than using a single value of the marker at baseline.

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T-Cell Activation